Desmosomes are junctions involved in intercellular adhesion of epithelial cells and hemidesmosomes are junctions involved in adhesion of epithelia to basement membranes. Both are characterised at the ultrastructural level by dense cytoplasmic plaques which are linked to the intermediate filament cytoskeleton of the cells. The plaques strongly resemble each other suggesting a relationship between the two kinds of junctions, as implied by their names. Recent characterisation of the molecular components of the junctions shows they are, in fact, quite unrelated implying (...) that structural similarity is fortuitous. The molecular biology raises many fascinating problems relating to their structure and function. (shrink)

The ultimate goal of the pioneering project outlined in this book is to map our genome--the key to what makes us human--in detail. The Code of Codes is a collective exploration of the substance and possible consequences of th is project in relation to ethics, law, and society.

There are methodological problems with the new techniques reviewed by Posner & Raichle. Some brain mechanisms are not detected by the temporal and spatial resolution. Questions are also raised by the stimulation paradigms.

The Representational Theory of Measurement (RTM), especially the canonical three volume Foundations of Measurement by Krantz et al., is a landmark accomplishment in our understanding of measurement. Despite this, it has been far from easy to pinpoint what exactly we can learn about measurement from RTM, and who the target audience for RTM’s formal results should be. In what sense does RTM provide foundations of measurement, and what is the philosophical significance of such foundations? I argue that RTM provides semantic (...) foundations of measurement, and that their philosophical significance lies in a shift towards structural representation. (shrink)

This paper offers a detailed account of arguments in De Caelo I by which Aristotle tried to demonstrate the necessity of the perpetual existence and the perpetual rotation of the cosmos. On our interpretation, Aristotle’s arguments are naturalistic. Instead of being based (as many have thought) on rules of logic and language, they depend, we argue, on natural science theories about abilities (δυνάμεις), e.g., to move and to change, which things have by nature and about the conditions under which these (...) abilities can be exercised. Our interpretation locates the De Caelo arguments in the context of some central doctrines of the Organon, the Metaphysics, the Physics, and other texts. The De Caelo arguments fit a number of views developed in these texts. Aristotle’s treatments of local motion, of natural motion and change, of necessity and possibility, and of abilities and their exercises are examples. But, as we interpret them, the De Caelo arguments raise serious questions about the role of (and the need for) Metaphysics A’s soulful Unmoved Mover in Aristotle’s overall natural-scientific picture. (shrink)

SummaryAs part of a prospective controlled study of the psychosomatic effects of elective tubal sterilization, 138 women were questioned about their menstrual functioning before sterilization, and again 6 months and 12 months post-operatively, using standardized interviewing procedures. Adverse changes, including increased menstrual loss, shorter menstrual cycles and greater use of pads or tampons were reported by sterilized subjects at both of the post-operative interviews. Control subjects reported several comparable effects, although adverse changes overall were reported more commonly by sterilized women (...) than by control subjects. However, many of the reported changes appeared to be related to pre-operative contraceptive methods, although consistent increases in use of pads or tampons were found in women who had pre-operatively used neither the pill nor the IUD. (shrink)

Sociologists studying gender have debated West and Zimmerman’s premise that “doing gender is unavoidable,” seeking to ascertain whether people can “undo” or only “redo” gender. While sociologists have been correct to focus on the interactional accomplishment of gender, they have neglected one of Garfinkel’s key insights about interaction: that people hold each other accountable to particular narratives. Neglecting the narrative aspect of doing—and undoing—gender impedes our ability to recognize processes of social change. Based on a qualitative study, we show how (...) the movement for LGBTQI acceptance within U.S. conservative Protestant churches works to make gender not “omnirelevant” by challenging conservative “complementarity” narratives that posit two complementary, opposite sexes as a commandment preceding the Ten Commandments in time and importance. We explore this movement’s ambivalent relationship with homonormativity, highlight three ways this movement resists projecting binary gender narratives into scripture, and examine how some in this movement see the pursuit of social justice as a Christian mandate. The efforts of LGBTQI conservative Christians exemplify how reshaping sex/gender/sexual narratives can create possibilities for undoing gender. (shrink)

In this article, we examine the ways gendered frames shift to make room for societal changes while maintaining existing pillars of systemic gender inequality. Utilizing the case of U.S. media representations of transgender people who reproduce, we analyze how media outlets make room for increasing societal recognition of transgender people and maintain cisnormative and repronormative traditions and beliefs in the process. Specifically, we outline how these media outlets accomplish both outcomes in two ways. First, they reinforce cisgender-based repronormativity via conceptualizations (...) of transgender reproduction as new and occurring in contrast to normative, cisgender reproduction. Second, they create a transnormative reproductive subject, which establishes a new socially sanctioned script for what it means to be transgender and what types of transgender experience may be recognized or accepted in mainstream society. In conclusion, we draw out implications for understanding how social authorities may shift existing gender frames to make room for changes in society while at the same time maintaining normative beliefs. These normative beliefs continue to facilitate societal patterns of gender inequality within such new frames. (shrink)

Medical education at the Colombian School of Medicine has undergone a reconceptualization and reorganization so as to encompasses three fundamental elements of medical practice: 1) development of general abilities and standards necessary for appropriate professional medical practice; 2) technical education which makes it possible to utilize the bases that science and technology have provided for the development and application of knowledge, and in turn, to expand this base through research and development; and 3) humanistic education to guide students into ethical (...) professional practice. (shrink)

He is the darling of naturalism or the bogeyman of scepticism, a friend to virtue or an unwitting party to incipient nihilism. He is politically conservative, or a liberator from old views. He is a fideist, an advocate of faith over reason, or a precursor of Richard Dawkins.

A provocative examination of the artistic interpretation of twelve of Borges’s most famous stories.